Development of sustained release fast-disintegrating tablets using various polymer-coated ion-exchange resin complexes

Seong Hoon Jeong, Kinam Park

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Complex formation between drugs and ion-exchange resins was investigated and the effects of coating by various aqueous polymeric dispersions on the complexes were evaluated for developing new sustained-release fast-disintegrating tablets (FDTs). Complexes of ion-exchange resin and dextromethorphan, a model drug, were prepared using different particle sizes of the resins. Aqueous colloidal dispersions of ethylcellulose (EC) and poly(vinyl acetate) (Kollicoat® SR30D) were used for fluid-bed coating. Based on drug loading, release profiles, and scanning electron microscopy (SEM) images, the coated particles were granulated with suitable tablet excipients and then compressed into the tablets. Drug release profiles and SEM pictures were compared before and after the manufacturing processes. As the particle size of resins increased, the drug loading and release rate decreased due to the reduced effective diffusion coefficient and surface area. Higher coating level decreased the release rate further. In contrast to EC, Kollicoat® SR30D coated particles could be compressed into tablets without any rupture or cracks on the coating since the mechanical properties of the polymer was more resistant to the manufacturing processes. This resulted in no significant changes in release rates. SEM showed the mechanical strength of the polymers affected the morphological change after compression. When the drug release profiles were applied into Boyd model and Higuchi equation, the linear relationship was observed, indicating that the diffusion within the resin matrix is the rate-controlling step.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume353
Issue number1-2
DOIs
StatePublished - 2 Apr 2008

Keywords

  • Diffusion
  • Ethylcellulose
  • Fast-disintegrating tablet
  • Fluid-bed coating
  • Ion-exchange resin
  • Polyvinyl acetate
  • Sustained release

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