Diagnostic usefulness of differential time to positivity in neutropenic cancer patients with suspected catheter-related candidemia

Kyeong Min Jo, Sungim Choi, Kyung Hwa Jung, Jung Wan Park, Ji Hyun Yun, Min Jae Kim, Yong Pil Chong, Sang Oh Lee, Sang Ho Choi, Yang Soo Kim, Jun Hee Woo, Jung Hee Lee, Je Hwan Lee, Kyoo Hyung Lee, Sung Han Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Methods for distinguishing catheter-related candidemia (CRC) from non-CRC before catheter removal remain limited. We thus evaluated the diagnostic performance of differential time to positivity (DTP) to diagnose CRC in neutropenic cancer patients with suspected CRC. Of the 35 patients enrolled, 15 (43%) with CRC (six definite and nine probable) and 17 (49%) with non-CRC were finally analyzed. Based on the receiver operating characteristic curve, the optimal cutoff value of DTP for diagnosing CRC was ≥1.45 hours with the sensitivity 80% (95% confidence interval [CI], 51-95) and specificity 100% (95% CI, 80-100), respectively.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalMedical Mycology
Volume58
Issue number1
DOIs
StatePublished - 1 Jan 2020

Keywords

  • candidemia
  • catheter
  • diagnosis
  • differential time to positivity
  • neutropenia

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