Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

Yujia Han; Jingjing Liu; Sungjin Ahn; Seungchan An; Hyejin Ko; Jeayoung C. Shin; Sun Hee Jin; Min Won Ki; So Hun Lee; Kang Hyuk Lee; Song Seok Shin; Won Jun Choi; Minsoo Noh

doi:10.4062/biomolther.2019.180

Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

Yujia Han, Jingjing Liu, Sungjin Ahn, Seungchan An, Hyejin Ko, Jeayoung C. Shin, Sun Hee Jin, Min Won Ki, So Hun Lee, Kang Hyuk Lee, Song Seok Shin, Won Jun Choi, Minsoo Noh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

Original language	English
Pages (from-to)	397-404
Number of pages	8
Journal	Biomolecules and Therapeutics
Volume	28
Issue number	5
DOIs	https://doi.org/10.4062/biomolther.2019.180
State	Published - 2020

Keywords

Adiponectin
Diallyl biphenyl-type neolignans
Human bone marrow mesenchymal stem cells
Peroxisome proliferator-activated receptor α/γ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4062/biomolther.2019.180

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@article{a679c4cc4560459797981b593872445e,

title = "Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators",

abstract = "Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.",

keywords = "Adiponectin, Diallyl biphenyl-type neolignans, Human bone marrow mesenchymal stem cells, Peroxisome proliferator-activated receptor α/γ",

author = "Yujia Han and Jingjing Liu and Sungjin Ahn and Seungchan An and Hyejin Ko and Shin, {Jeayoung C.} and Jin, {Sun Hee} and Ki, {Min Won} and Lee, {So Hun} and Lee, {Kang Hyuk} and Shin, {Song Seok} and Choi, {Won Jun} and Minsoo Noh",

note = "Publisher Copyright: {\textcopyright} 2020 The Korean Society of Applied Pharmacology.",

year = "2020",

doi = "10.4062/biomolther.2019.180",

language = "English",

volume = "28",

pages = "397--404",

journal = "Biomolecules and Therapeutics",

issn = "1976-9148",

publisher = "Korean Society of Applied Pharmacology",

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}

TY - JOUR

T1 - Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

AU - Han, Yujia

AU - Liu, Jingjing

AU - Ahn, Sungjin

AU - An, Seungchan

AU - Ko, Hyejin

AU - Shin, Jeayoung C.

AU - Jin, Sun Hee

AU - Ki, Min Won

AU - Lee, So Hun

AU - Lee, Kang Hyuk

AU - Shin, Song Seok

AU - Choi, Won Jun

AU - Noh, Minsoo

PY - 2020

Y1 - 2020

N2 - Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

AB - Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

KW - Adiponectin

KW - Diallyl biphenyl-type neolignans

KW - Human bone marrow mesenchymal stem cells

KW - Peroxisome proliferator-activated receptor α/γ

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U2 - 10.4062/biomolther.2019.180

DO - 10.4062/biomolther.2019.180

M3 - Article

AN - SCOPUS:85093905745

SN - 1976-9148

VL - 28

SP - 397

EP - 404

JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

IS - 5

ER -

Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

Abstract

Keywords

UN SDGs

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