Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

Yujia Han; Jingjing Liu; Sungjin Ahn; Seungchan An; Hyejin Ko; Jeayoung C. Shin; Sun Hee Jin; Min Won Ki; So Hun Lee; Kang Hyuk Lee; Song Seok Shin; Won Jun Choi; Minsoo Noh

doi:10.4062/biomolther.2019.180

Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

Yujia Han
, Jingjing Liu
, Sungjin Ahn
, Seungchan An
, Hyejin Ko
, Jeayoung C. Shin
, Sun Hee Jin
, Min Won Ki
, So Hun Lee
, Kang Hyuk Lee
, Song Seok Shin
, Won Jun Choi
, Minsoo Noh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

Original language	English
Pages (from-to)	397-404
Number of pages	8
Journal	Biomolecules and Therapeutics
Volume	28
Issue number	5
DOIs	https://doi.org/10.4062/biomolther.2019.180
State	Published - 2020

Keywords

Adiponectin
Diallyl biphenyl-type neolignans
Human bone marrow mesenchymal stem cells
Peroxisome proliferator-activated receptor α/γ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4062/biomolther.2019.180

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@article{a679c4cc4560459797981b593872445e,

title = "Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators",

abstract = "Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.",

keywords = "Adiponectin, Diallyl biphenyl-type neolignans, Human bone marrow mesenchymal stem cells, Peroxisome proliferator-activated receptor α/γ",

author = "Yujia Han and Jingjing Liu and Sungjin Ahn and Seungchan An and Hyejin Ko and Shin, \{Jeayoung C.\} and Jin, \{Sun Hee\} and Ki, \{Min Won\} and Lee, \{So Hun\} and Lee, \{Kang Hyuk\} and Shin, \{Song Seok\} and Choi, \{Won Jun\} and Minsoo Noh",

note = "Publisher Copyright: {\textcopyright} 2020 The Korean Society of Applied Pharmacology.",

year = "2020",

doi = "10.4062/biomolther.2019.180",

language = "English",

volume = "28",

pages = "397--404",

journal = "Biomolecules and Therapeutics",

issn = "1976-9148",

publisher = "Korean Society of Applied Pharmacology",

number = "5",

}

TY - JOUR

T1 - Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

AU - Han, Yujia

AU - Liu, Jingjing

AU - Ahn, Sungjin

AU - An, Seungchan

AU - Ko, Hyejin

AU - Shin, Jeayoung C.

AU - Jin, Sun Hee

AU - Ki, Min Won

AU - Lee, So Hun

AU - Lee, Kang Hyuk

AU - Shin, Song Seok

AU - Choi, Won Jun

AU - Noh, Minsoo

PY - 2020

Y1 - 2020

N2 - Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

AB - Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adipo-nectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

KW - Adiponectin

KW - Diallyl biphenyl-type neolignans

KW - Human bone marrow mesenchymal stem cells

KW - Peroxisome proliferator-activated receptor α/γ

UR - https://www.scopus.com/pages/publications/85093905745

U2 - 10.4062/biomolther.2019.180

DO - 10.4062/biomolther.2019.180

M3 - Article

AN - SCOPUS:85093905745

SN - 1976-9148

VL - 28

SP - 397

EP - 404

JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

IS - 5

ER -

Diallyl biphenyl-type neolignans have a pharmacophore of pparα/γ dual modulators

Abstract

Keywords

UN SDGs

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