TY - JOUR
T1 - Dielectrophoretic force-induced wrinkling of graphene oxide
T2 - Enhancing electrical conductivity and expanding biosensing applications
AU - Park, Yejin
AU - Kim, Hyejin
AU - Song, Jaeyoon
AU - Kim, Sehyeon
AU - Lee, Byung Chul
AU - Kim, Jinsik
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Graphene oxide (GO) has many advantages, making it suitable for various applications. However, it has low electrical conductivity, restricting its applicability to electrochemical biosensors. This study used dielectrophoretic (DEP) force to control the movement and deformation of GO nanosheets to achieve high electrical conductivity without the chemical reduction of oxygen functional groups. Subjecting the DEP force to GO nanosheets induced physical deformation leading to the formation of wrinkled structures. A computational simulation was performed to set an appropriate electrical condition for operating a positive DEP force effect of at least 1019 v2/m3, and the interdigitated microelectrode structure was selected. The resulting wrinkled GO exhibited significantly improved electrical conductivity, reaching 21.721 μS while preserving the essential oxygen functional groups. Furthermore, a biosensor was fabricated using wrinkled GO deposited via DEP force. The biosensor demonstrated superior sensitivity, exhibiting a 9.6-fold enhancement compared with reduced GO (rGO) biosensors, as demonstrated through biological experiments targeting inducible nitric oxide synthase. This study highlights the potential of using DEP force to enhance electrical conductivity in GO-based biosensing applications, opening new avenues for high-performance diagnostics.
AB - Graphene oxide (GO) has many advantages, making it suitable for various applications. However, it has low electrical conductivity, restricting its applicability to electrochemical biosensors. This study used dielectrophoretic (DEP) force to control the movement and deformation of GO nanosheets to achieve high electrical conductivity without the chemical reduction of oxygen functional groups. Subjecting the DEP force to GO nanosheets induced physical deformation leading to the formation of wrinkled structures. A computational simulation was performed to set an appropriate electrical condition for operating a positive DEP force effect of at least 1019 v2/m3, and the interdigitated microelectrode structure was selected. The resulting wrinkled GO exhibited significantly improved electrical conductivity, reaching 21.721 μS while preserving the essential oxygen functional groups. Furthermore, a biosensor was fabricated using wrinkled GO deposited via DEP force. The biosensor demonstrated superior sensitivity, exhibiting a 9.6-fold enhancement compared with reduced GO (rGO) biosensors, as demonstrated through biological experiments targeting inducible nitric oxide synthase. This study highlights the potential of using DEP force to enhance electrical conductivity in GO-based biosensing applications, opening new avenues for high-performance diagnostics.
KW - Biosensor
KW - Chemical reduction
KW - Dielectrophoretic force
KW - Electrical conductivity
KW - Graphene oxide
KW - Wrinkles
UR - http://www.scopus.com/inward/record.url?scp=85179586074&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2023.115867
DO - 10.1016/j.bios.2023.115867
M3 - Article
C2 - 38086307
AN - SCOPUS:85179586074
SN - 0956-5663
VL - 246
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 115867
ER -