Diffusion properties of different compounds across various synthetic membranes using Franz-type diffusion cells

Youn Jung Jung, Jeong Hyun Yoon, Nae Gyu Kang, Sun Gyoo Park, Seong Hoon Jeong

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Diffusion properties of typical functional cosmetic ingredients, niacinamide, ascorbic acid 2-glucoside, retinol and polyethoxylated retinamide, were evaluated across various synthetic membranes using Franz-type diffusion cells. Different kinds of artificial membranes available in the market were utilized for comparing how the functional ingredients diffuse through the membrane. Niacinamide and ascorbic acid 2-glucoside were resulted out similar diffusion pattern. On the other hands, retinol and polyethoxylated retinamide showed similar diffusion pattern. This might be due to their hydrophilic properties. Moreover, physicochemical properties of the membranes, pore size, and/or membrane thickness need to be considered as well. Solvents and composition of the donor and receptor compartment are the factors to investigate in detail to obtain systematic information regarding the diffusion properties. The results might help when to evaluate and analyze topical formulations in a faster and reproducible way.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalJournal of Pharmaceutical Investigation
Volume42
Issue number5
DOIs
StatePublished - Oct 2012

Keywords

  • Ascorbic acid 2-glucoside
  • Diffusion
  • Franz cell
  • Niacinamide
  • Polyethoxylated retinamide
  • Retinol
  • Synthetic membrane

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