Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

Shinae Lee, Min Gyung Son, Young Mi Kim, Chae Yeong An, Hyun Ji Kim, Piseth Nhoek, Pisey Pel, Hongic Won, Yoonkyung Lee, Narae Yun, Jin Hyub Paik, Badamtsetseg Bazarragchaa, Hyun Woo Kim, Young Hee Choi, Won Keun Oh, Chang Hoon Lee, Young Won Chin

Research output: Contribution to journalArticlepeer-review

Abstract

The isolation of previously undescribed 12 compounds from the MeOH extract of Jacobaea vulgaris whole plants is disclosed, comprising 11 dihydrostilbenes (1–11) and one flavanone (12), and eight known compounds (six flavonoids, one dihydrostilbene, and one caffeoylquinic acid). Structural elucidation employed spectroscopic methods, including 1D and 2D NMR spectroscopy, HRESIMS, and ECD calculations. Evaluation of the compounds’ effects on PCSK9 and LDLR mRNA expression revealed that compounds 1 and 3 downregulated PCSK9 mRNA while increasing LDLR mRNA expression, suggesting potential cholesterol-lowering properties.

Original languageEnglish
Article number114107
JournalPhytochemistry
Volume222
DOIs
StatePublished - Jun 2024

Keywords

  • Asteraceae
  • Dihydrostilbenes
  • Flavonoids
  • Jacobaea vulgaris
  • LDLR
  • PCSK9

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