TY - JOUR
T1 - Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individuals
AU - Chang, Yujung
AU - Cho, Byounggook
AU - Kim, Siyoung
AU - Kim, Jongpil
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Mortality caused by age-related bone fractures or osteoporosis is steadily increasing worldwide as the population ages. The pace of the development of bone regeneration engineering to treat bone fractures has consequently increased in recent years. A range of techniques for bone regeneration, such as immunotherapy, allografts, and hydrogel therapy, have been devised. Cell-based therapies using bone marrow-derived mesenchymal stem cells and induced pluripotent stem cells derived from somatic cells are considered to be suitable approaches for bone repair. However, these cell-based therapies suffer from a number of limitations in terms of efficiency and safety. Somatic cells can also be directly differentiated into osteoblasts by several transcription factors. As osteoblasts play a central role in the process of bone formation, the direct reprogramming of fibroblasts into osteoblasts may hence be a new way to treat bone fractures in elderly individuals. Here, we review recent developments regarding the therapeutic potential of the direct reprogramming of cells for bone regeneration.
AB - Mortality caused by age-related bone fractures or osteoporosis is steadily increasing worldwide as the population ages. The pace of the development of bone regeneration engineering to treat bone fractures has consequently increased in recent years. A range of techniques for bone regeneration, such as immunotherapy, allografts, and hydrogel therapy, have been devised. Cell-based therapies using bone marrow-derived mesenchymal stem cells and induced pluripotent stem cells derived from somatic cells are considered to be suitable approaches for bone repair. However, these cell-based therapies suffer from a number of limitations in terms of efficiency and safety. Somatic cells can also be directly differentiated into osteoblasts by several transcription factors. As osteoblasts play a central role in the process of bone formation, the direct reprogramming of fibroblasts into osteoblasts may hence be a new way to treat bone fractures in elderly individuals. Here, we review recent developments regarding the therapeutic potential of the direct reprogramming of cells for bone regeneration.
UR - http://www.scopus.com/inward/record.url?scp=85065594162&partnerID=8YFLogxK
U2 - 10.1038/s12276-019-0251-1
DO - 10.1038/s12276-019-0251-1
M3 - Review article
C2 - 31073120
AN - SCOPUS:85065594162
SN - 1226-3613
VL - 51
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 5
M1 - 54
ER -