TY - JOUR
T1 - Direct thrombus imaging in stroke
AU - Kim, Jongseong
AU - Park, Jung E.
AU - Nahrendorf, Matthias
AU - Kim, Dong Eog
N1 - Publisher Copyright:
© 2016 Korean Stroke Society.
PY - 2016/9
Y1 - 2016/9
N2 - There is an emergent need for imaging methods to better triage patients with acute stroke for tissue-plasminogen activator (tPA)-mediated thrombolysis or endovascular clot retrieval by directly visualizing the size and distribution of cerebral thromboemboli. Currently, magnetic resonance (MR) or computed tomography (CT) angiography visualizes the obstruction of blood flow within the vessel lumen rather than the thrombus itself. The present visualization method, which relies on observation of the dense artery sign (the appearance of cerebral thrombi on a non-enhanced CT), suffers from low sensitivity. When translated into the clinical setting, direct thrombus imaging is likely to enable individualized acute stroke therapy by allowing clinicians to detect the thrombus with high sensitivity, assess the size and nature of the thrombus more precisely, serially monitor the therapeutic effects of thrombolysis, and detect post-treatment recurrence. This review is intended to provide recent updates on stroke-related direct thrombus imaging using MR imaging, positron emission tomography, or CT.
AB - There is an emergent need for imaging methods to better triage patients with acute stroke for tissue-plasminogen activator (tPA)-mediated thrombolysis or endovascular clot retrieval by directly visualizing the size and distribution of cerebral thromboemboli. Currently, magnetic resonance (MR) or computed tomography (CT) angiography visualizes the obstruction of blood flow within the vessel lumen rather than the thrombus itself. The present visualization method, which relies on observation of the dense artery sign (the appearance of cerebral thrombi on a non-enhanced CT), suffers from low sensitivity. When translated into the clinical setting, direct thrombus imaging is likely to enable individualized acute stroke therapy by allowing clinicians to detect the thrombus with high sensitivity, assess the size and nature of the thrombus more precisely, serially monitor the therapeutic effects of thrombolysis, and detect post-treatment recurrence. This review is intended to provide recent updates on stroke-related direct thrombus imaging using MR imaging, positron emission tomography, or CT.
KW - Acute stroke
KW - Direct thrombus imaging
KW - Magnetic resonance imaging
KW - Molecular imaging
KW - Positron-emission tomography
KW - X-ray computed tomography
UR - http://www.scopus.com/inward/record.url?scp=84990031935&partnerID=8YFLogxK
U2 - 10.5853/jos.2016.00906
DO - 10.5853/jos.2016.00906
M3 - Review article
AN - SCOPUS:84990031935
SN - 2287-6391
VL - 18
SP - 286
EP - 296
JO - Journal of Stroke
JF - Journal of Stroke
IS - 3
ER -