Abstract
A GO-to solution: A simple graphene oxide (GO)-based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selective for the HCV helicase orthologous to the SARS CoV helicase. Some of these hits were validated using the same GO-based assay.
Original language | English |
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Pages (from-to) | 2340-2344 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 8 |
DOIs | |
State | Published - 18 Feb 2013 |
Keywords
- biosensors
- graphene oxide
- helicases
- high-throughput screening
- multiplex assays