Discovery of hepatitis C virus NS5A inhibitors as a new class of anti-HCV therapy

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Abstract

Chronic hepatitis C virus (HCV) infection is responsible for development of liver cirrhosis and hepatocellular carcinoma. In addition to PEGylated interferon-α, ribavirin, and HCV NS3 protease inhibitors, recently identified HCV NS5A inhibitors such as BMS-790052 showed a great promise in clinical trials as another new class of direct-acting anti-HCV therapeutics with a distinct mechanism of action. This clinical proof-of-concept study with NS5A inhibitors demonstrated that small molecules targeting a viral protein without any known enzymatic activity can also have profound antiviral effects. In conclusion, NS5A inhibitors will serve as a valuable component of future therapy for HCV patients.

Original languageEnglish
Pages (from-to)1403-1407
Number of pages5
JournalArchives of Pharmacal Research
Volume34
Issue number9
DOIs
StatePublished - Sep 2011

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