Dose-dependent pharmacokinetics of SP-8203 in rats

Joo H. Lee; Young H. Choi; Jung H. Suh; Hee E. Kang; Tae H. Lee; Il H. Cho; Myung G. Lee

doi:10.1002/bdd.713

Dose-dependent pharmacokinetics of SP-8203 in rats

Joo H. Lee, Young H. Choi, Jung H. Suh, Hee E. Kang, Tae H. Lee, Il H. Cho, Myung G. Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The pharmacokinetics of SP-8203, a potential protective agent for the treatment of cerebral infarction, were evaluated after its intravenous (10, 20 and 30 mg/kg) and oral (10, 20, 30 and 100 mg/kg) administration in rats. After the intravenous administration of SP-8203, the AUCs of SP-8203 were dose-dependent; the dose-normalized AUCs were significantly greater with increasing doses. After the oral administration of SP-8203, plasma concentrations of SP-8203 were much lower than those after intravenous administration. This could be due to considerable hepatic and intestinal metabolism and the high percent of the dose recovered from the gastrointestinal tract (including its contents and feces) at 24 h as unchanged drug.

Original language	English
Pages (from-to)	358-361
Number of pages	4
Journal	Biopharmaceutics and Drug Disposition
Volume	31
Issue number	5-6
DOIs	https://doi.org/10.1002/bdd.713
State	Published - 2010

Keywords

Dose-dependent pharmacokinetics
Intravenous and oral administration
Rats
SP-8203

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10.1002/bdd.713

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abstract = "The pharmacokinetics of SP-8203, a potential protective agent for the treatment of cerebral infarction, were evaluated after its intravenous (10, 20 and 30 mg/kg) and oral (10, 20, 30 and 100 mg/kg) administration in rats. After the intravenous administration of SP-8203, the AUCs of SP-8203 were dose-dependent; the dose-normalized AUCs were significantly greater with increasing doses. After the oral administration of SP-8203, plasma concentrations of SP-8203 were much lower than those after intravenous administration. This could be due to considerable hepatic and intestinal metabolism and the high percent of the dose recovered from the gastrointestinal tract (including its contents and feces) at 24 h as unchanged drug.",

keywords = "Dose-dependent pharmacokinetics, Intravenous and oral administration, Rats, SP-8203",

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AU - Lee, Joo H.

AU - Choi, Young H.

AU - Suh, Jung H.

AU - Kang, Hee E.

AU - Lee, Tae H.

AU - Cho, Il H.

AU - Lee, Myung G.

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AB - The pharmacokinetics of SP-8203, a potential protective agent for the treatment of cerebral infarction, were evaluated after its intravenous (10, 20 and 30 mg/kg) and oral (10, 20, 30 and 100 mg/kg) administration in rats. After the intravenous administration of SP-8203, the AUCs of SP-8203 were dose-dependent; the dose-normalized AUCs were significantly greater with increasing doses. After the oral administration of SP-8203, plasma concentrations of SP-8203 were much lower than those after intravenous administration. This could be due to considerable hepatic and intestinal metabolism and the high percent of the dose recovered from the gastrointestinal tract (including its contents and feces) at 24 h as unchanged drug.

KW - Dose-dependent pharmacokinetics

KW - Intravenous and oral administration

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Dose-dependent pharmacokinetics of SP-8203 in rats

Abstract

Keywords

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