Double modification of electrode surface for the selective detection of epinephrine and its application to flow injection amperometric analysis

Guang Ri Xu, Xin hua Qi, Fengxia Yang, Jae Joon Lee, Ming Lu Xu, Yu Ping Zhang, Sunghyun Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A glassy carbon electrode having two polymer layers has been applied to selectively detect epinephrine. The inner layer formed by electropolymerization of macrocyclic nickel complex functioned as an electrocatalyst for epinephrine oxidation and the outer layer composed of hydrolyzed polyurethane g-benzyl l-glutamate as a screening layer. Differential pulse voltammetry showed almost 100% recovery of epinephrine even in 100-fold excess of interferents. When applied to a dual glassy carbon electrode as an amperometric detector in flow injection analysis, a linear response over 0.1 mM and 10 mM was obtained. Recovery tested for 5-fold diluted human urine samples was 97.5%.

Original languageEnglish
Pages (from-to)2486-2490
Number of pages5
JournalElectroanalysis
Volume21
Issue number22
DOIs
StatePublished - Nov 2009

Keywords

  • Differential pulse voltammetry
  • Double modification
  • Epinephrine
  • Flow injection analysis
  • Medicinal chemistry
  • Ni(ii) macrocyclic complex

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