Drug-ceramic 2-dimensional nanoassemblies for drug delivery system in physiological condition

Goeun Choi, Su Yeon Kim, Jae Min Oh, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The anticancer drug methotrexate (MTX) was successfully incorporated into the layered ceramic nanoparticles of layered double hydroxides (LDHs). The prepared MTX-LDH two-dimensional nanoassemblies showed enhanced chemical and thermal stability of intercalated MTX molecules through the effective electrostatic interaction with ceramic LDH layers. And the surface charge of MTX-LDHs was determined to be highly positive whereas that of MTX is fairly negative. The anticancer effect of MTX-LDH compared with MTX was evaluated in the human osteosarcoma cell culture line SaOS-2, showing much faster drug efficacy with low concentration. The time-dependent cellular uptake of MTX determined by high performance liquid chromatography showed the much enhanced cellular drug concentration of MTX-LDH treated cancer cells than the MTX treated ones. The particle size of MTX-LDH nanoassemblies was estimated in various solutions such as saline, phosphate saline, and RPMI 1640 cell culture medium, showing that the hydrodynamic size maintains at ∼100 nm, regardless of the suspension media. The positive surface charge and ∼100 nm size of MTX-LDHs is considered to be the major factor in the high cellular uptake and enhanced drug efficacy.

Original languageEnglish
Pages (from-to)2758-2765
Number of pages8
JournalJournal of the American Ceramic Society
Volume95
Issue number9
DOIs
StatePublished - Sep 2012

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