Drug-induced hyperbilirubinemia and the clinical influencing factors

Young Mi Ah, Young Mi Kim, Min Jung Kim, Young Hee Choi, Kyoung Ho Park, In Ja Son, Sang Geon Kim

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs. Clinical drugs are the important causes of hyperbilirubinemia, especially for patients with certain pathologic conditions or with genetic variations. This article reviews hyperbilirubinemic pathophysiology with respect to the effects of clinical drugs. In addition, this review introduces a new formula that may be utilized to estimate the annual occurrences of drug-induced hyperbilirubinemia in a hospital. Variations in the genes of UDP-glucuronosyltransferases, organic anion-transporting polypeptides and multidrug resistance proteins are the predisposing factors for drug-induced hyperbilirubinemia; therefore, their genetic and ethnic polymorphisms are discussed.

Original languageEnglish
Pages (from-to)511-537
Number of pages27
JournalDrug Metabolism Reviews
Volume40
Issue number4
DOIs
StatePublished - Oct 2008

Keywords

  • Adverse drug reactions
  • Annual occurrence indices
  • Genetic polymorphisms
  • Hyperbilirubinemia
  • Multidrug resistance-associated protein 2 (MRA2)
  • OATP1B1
  • UGT1A1

Fingerprint

Dive into the research topics of 'Drug-induced hyperbilirubinemia and the clinical influencing factors'. Together they form a unique fingerprint.

Cite this