Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens

Jong Seob Jeong; Ruimin Chen; Qifa Zhou; Amir Kashani; Mark Humayun; K. Kirk Shung

doi:10.1109/ULTSYM.2012.0208

Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens

Jong Seob Jeong, Ruimin Chen, Qifa Zhou, Amir Kashani, Mark Humayun, K. Kirk Shung

Department of Biomedical Engineering

University of Southern California

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

A preliminary feasibility study on the breaking of a cataractous lens noninvasively through acoustic cavitation is presented. Instead of the conventional invasive method called phacoemulsification, the noninvasive ultrasound sonication scheme was used to generate micro-cracks in the target. For more enhanced cavitation, a dual-frequency approach was employed using the dual-concentric ultrasound transducer capable of simultaneously emitting 1.6 MHz and 4 MHz ultrasound. The dual-frequency ultrasound generated more microcracks in a cataractous porcine lens compared to 1.6 MHz single frequency sonication. This study shows that the proposed noninvasive ultrasound scheme based on dual-frequency acoustic cavitation may be a potentially viable approach for treating cataract in the future.

Original language	English
Title of host publication	2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages	835-838
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2012.0208
State	Published - 2012
Event	2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany Duration: 7 Oct 2012 → 10 Oct 2012

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2012 IEEE International Ultrasonics Symposium, IUS 2012
Country/Territory	Germany
City	Dresden
Period	7/10/12 → 10/10/12

Access to Document

10.1109/ULTSYM.2012.0208

Cite this

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title = "Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens",

abstract = "A preliminary feasibility study on the breaking of a cataractous lens noninvasively through acoustic cavitation is presented. Instead of the conventional invasive method called phacoemulsification, the noninvasive ultrasound sonication scheme was used to generate micro-cracks in the target. For more enhanced cavitation, a dual-frequency approach was employed using the dual-concentric ultrasound transducer capable of simultaneously emitting 1.6 MHz and 4 MHz ultrasound. The dual-frequency ultrasound generated more microcracks in a cataractous porcine lens compared to 1.6 MHz single frequency sonication. This study shows that the proposed noninvasive ultrasound scheme based on dual-frequency acoustic cavitation may be a potentially viable approach for treating cataract in the future.",

author = "Jeong, {Jong Seob} and Ruimin Chen and Qifa Zhou and Amir Kashani and Mark Humayun and Shung, {K. Kirk}",

year = "2012",

doi = "10.1109/ULTSYM.2012.0208",

language = "English",

isbn = "9781467345613",

series = "IEEE International Ultrasonics Symposium, IUS",

pages = "835--838",

booktitle = "2012 IEEE International Ultrasonics Symposium, IUS 2012",

note = "2012 IEEE International Ultrasonics Symposium, IUS 2012 ; Conference date: 07-10-2012 Through 10-10-2012",

}

Jeong, JS, Chen, R, Zhou, Q, Kashani, A, Humayun, M & Shung, KK 2012, Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6561949, IEEE International Ultrasonics Symposium, IUS, pp. 835-838, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 7/10/12. https://doi.org/10.1109/ULTSYM.2012.0208

Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens. / Jeong, Jong Seob; Chen, Ruimin; Zhou, Qifa et al.
2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 835-838 6561949 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens

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AU - Shung, K. Kirk

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N2 - A preliminary feasibility study on the breaking of a cataractous lens noninvasively through acoustic cavitation is presented. Instead of the conventional invasive method called phacoemulsification, the noninvasive ultrasound sonication scheme was used to generate micro-cracks in the target. For more enhanced cavitation, a dual-frequency approach was employed using the dual-concentric ultrasound transducer capable of simultaneously emitting 1.6 MHz and 4 MHz ultrasound. The dual-frequency ultrasound generated more microcracks in a cataractous porcine lens compared to 1.6 MHz single frequency sonication. This study shows that the proposed noninvasive ultrasound scheme based on dual-frequency acoustic cavitation may be a potentially viable approach for treating cataract in the future.

AB - A preliminary feasibility study on the breaking of a cataractous lens noninvasively through acoustic cavitation is presented. Instead of the conventional invasive method called phacoemulsification, the noninvasive ultrasound sonication scheme was used to generate micro-cracks in the target. For more enhanced cavitation, a dual-frequency approach was employed using the dual-concentric ultrasound transducer capable of simultaneously emitting 1.6 MHz and 4 MHz ultrasound. The dual-frequency ultrasound generated more microcracks in a cataractous porcine lens compared to 1.6 MHz single frequency sonication. This study shows that the proposed noninvasive ultrasound scheme based on dual-frequency acoustic cavitation may be a potentially viable approach for treating cataract in the future.

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SP - 835

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BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012

T2 - 2012 IEEE International Ultrasonics Symposium, IUS 2012

Y2 - 7 October 2012 through 10 October 2012

ER -

Dual-frequency acoustic cavitation for noninvasively breaking down a cataractous lens

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