Dual-growth-factor-releasing PCL scaffolds for chondrogenesis of adipose-tissue-derived mesenchymal stem cells

Sung Mook Lim; Sung Hwan Jang; Se Heang Oh; Soon Hong Yuk; Gun Il Im; Jin Ho Lee

doi:10.1002/adem.200980153

Dual-growth-factor-releasing PCL scaffolds for chondrogenesis of adipose-tissue-derived mesenchymal stem cells

Sung Mook Lim, Sung Hwan Jang, Se Heang Oh, Soon Hong Yuk, Gun Il Im, Jin Ho Lee

Department of Medicine

Hannam University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have opencellular pore structures. Growth factors (TGF-β2, BMP-7 or dual TGF-β2/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growthfactor- immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β2 and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.

Original language	English
Pages (from-to)	B62-B69
Journal	Advanced Engineering Materials
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1002/adem.200980153
State	Published - Feb 2010

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abstract = "Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have opencellular pore structures. Growth factors (TGF-β2, BMP-7 or dual TGF-β2/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growthfactor- immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β2 and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.",

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AU - Jang, Sung Hwan

AU - Oh, Se Heang

AU - Yuk, Soon Hong

AU - Im, Gun Il

AU - Lee, Jin Ho

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AB - Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have opencellular pore structures. Growth factors (TGF-β2, BMP-7 or dual TGF-β2/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growthfactor- immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β2 and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.

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ER -

Dual-growth-factor-releasing PCL scaffolds for chondrogenesis of adipose-tissue-derived mesenchymal stem cells

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