Abstract
Dual Rh(II)/Pd(0) relay catalysis of N-sulfonyl triazoles and 2-hydroxymethylallyl carbonates has been developed, which affords N-sulfonyl pyrrolidines in moderate to good yields with high diastereoselectivities. The reaction proceeds via a relay mechanism involving O-H insertion onto the α-imino Rh(II)-carbene, [3,3]-sigmatropic rearrangement, dipole formation through Pd(0)-catalyzed decarboxylation, and intramolecular N-allylation, leading to the formation of multiple bonds in a one-pot operation.
Original language | English |
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Pages (from-to) | 6951-6956 |
Number of pages | 6 |
Journal | Organic Letters |
Volume | 24 |
Issue number | 38 |
DOIs | |
State | Published - 30 Sep 2022 |