Dual-Wavelength Irradiation and Dox Delivery for -Cancer Cell Ablation with Photocatalytic Pr Doped TiO2/NGO -Hybrid Nanocomposite

Hongje Jang; Myung Ho Choi; Yeajee Yim; Young Kwan Kim; Dal Hee Min

doi:10.1002/adhm.201500157

Dual-Wavelength Irradiation and Dox Delivery for -Cancer Cell Ablation with Photocatalytic Pr Doped TiO₂/NGO -Hybrid Nanocomposite

Hongje Jang
, Myung Ho Choi
, Yeajee Yim
, Young Kwan Kim
, Dal Hee Min

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Herein, hybrid nanocomposite of praseodymium doped TiO₂ nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO₂/NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO₂. Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near-infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.

Original language	English
Pages (from-to)	1833-1840
Number of pages	8
Journal	Advanced Healthcare Materials
Volume	4
Issue number	12
DOIs	https://doi.org/10.1002/adhm.201500157
State	Published - 1 Aug 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer therapy
Drug delivery
Graphene oxide
Photodynamic therapy
Photothermal therapy

Access to Document

10.1002/adhm.201500157

Cite this

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title = "Dual-Wavelength Irradiation and Dox Delivery for -Cancer Cell Ablation with Photocatalytic Pr Doped TiO2/NGO -Hybrid Nanocomposite",

abstract = "Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2/NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO2. Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near-infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.",

keywords = "Cancer therapy, Drug delivery, Graphene oxide, Photodynamic therapy, Photothermal therapy",

author = "Hongje Jang and Choi, \{Myung Ho\} and Yeajee Yim and Kim, \{Young Kwan\} and Min, \{Dal Hee\}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

month = aug,

day = "1",

doi = "10.1002/adhm.201500157",

language = "English",

volume = "4",

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journal = "Advanced Healthcare Materials",

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T1 - Dual-Wavelength Irradiation and Dox Delivery for -Cancer Cell Ablation with Photocatalytic Pr Doped TiO2/NGO -Hybrid Nanocomposite

AU - Jang, Hongje

AU - Choi, Myung Ho

AU - Yim, Yeajee

AU - Kim, Young Kwan

AU - Min, Dal Hee

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2/NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO2. Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near-infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.

AB - Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2/NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO2. Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near-infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.

KW - Cancer therapy

KW - Drug delivery

KW - Graphene oxide

KW - Photodynamic therapy

KW - Photothermal therapy

UR - https://www.scopus.com/pages/publications/84940440313

U2 - 10.1002/adhm.201500157

DO - 10.1002/adhm.201500157

M3 - Article

C2 - 26085286

AN - SCOPUS:84940440313

SN - 2192-2640

VL - 4

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