Effect of a Scaffold Fabricated Thermally from Acetylated PLGA on the Formation of Engineered Cartilage

Sun Woong Kang, Suk Jun Lee, Jin Su Kim, Eun Hee Choi, Byung Hyun Cha, Jin Hyung Shim, Dong Woo Cho, Soo Hong Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A MHDS has been employed to fabricate 3D scaffolds from PLGA with acetyl endgroups to achieve in vivo regeneration of cartilage tissue. The fabricated acetylated-PLGA scaffold showed open pores and interconnected structures. Rabbit chondrocytes were seeded on the PLGA scaffolds and transplanted immediately into subcutaneous sites of athymic mice. Chondrocytes transplantation with untreated PLGA scaffolds served as a control. Histological analysis of the implants at 4 weeks with H&E staining and alcian blue staining revealed higher extracellular matrix and GAG expression at the neocartilage in the PLGA-6Ac scaffolds than that of the PLGA-6OH scaffold group. This endgroup-modified scaffold may be useful for successful cartilage tissue engineering in orthopedic applications. Cartilage tissue engineering using polymer scaffolds could be an alternative option to treat cartilage injury. However, acidic conditions of the extracellular matrix has shown negative effects in chondrocytes. The acetylation of endgroup of PLGA would increase thermal stability. The increased thermal stability would be able to reduce degradation rate of biodegradable polymers and acidification of the extracellular matrix.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalMacromolecular Bioscience
Volume11
Issue number2
DOIs
StatePublished - 1 Feb 2011

Keywords

  • Biodegradable
  • Biological applications of polymers
  • Biomaterials
  • Degradation
  • Tissue engineering

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