Effect of atorvastatin on the intravenous and oral pharmacokinetics of verapamil in rats

Dong Hyun Choi, Kyong Sig Chang, Soon Pyo Hong, Jun Shik Choi, Hyo Kyung Han

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14 Scopus citations

Abstract

The present study aimed to investigate the effect of atorvastatin on the intravenous and oral pharmacokinetics of verapamil in rats. The pharmacokinetic parameters of verapamil were measured after an oral (9 mg/kg) or intravenous (3 mg/kg) administration of verapamil to rats in the presence and absence of atorvastatin. Compared with the control given verapamil alone, the concurrent use of 1.5 mg/kg of atorvastatin significantly increased the oral exposure of verapamil in rats. The AUC and Cmax of verapamil increased by 70% and 61%, respectively in the presence of atorvastatin (1.5 mg/kg), while there was no significant change in Tmax and the terminal plasma half-life (T1/2) of verapamil. Accordingly, the presence of atorvastatin significantly (p<0.05) increased the bioavailability of verapamil in rats. In contrast, atorvastatin had no effect on any pharmacokinetic parameters of verapamil given intravenously, implying that atorvastatin may improve the oral bioavailability of verapamil by reducing the prehepatic extraction of verapamil most likely mediated by P-gp and/or CYP3A4. In conclusion, coadministration of atorvastatin significantly enhanced the oral exposure of verapamil in rats without a change in the systemic clearance of intravenous verapamil, suggesting a potential drug interaction between verapamil and atorvastatin via the modulation of prehepatic extraction.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalBiopharmaceutics and Drug Disposition
Volume29
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Atorvastatin
  • CYP3A4
  • P-gp
  • Pharmacokinetics
  • Verapamil

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