Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide

Jung Woo Bae, Kyung Yul Oh, So Jung Yoon, Hyo Bin Shin, Eui Hyun Jung, Chang Keun Cho, Chang Woo Lim, Pureum Kang, Chang Ik Choi, Choon Gon Jang, Seok Yong Lee, Yun Jeong Lee

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Metoclopramide inhibits the central and peripheral D2 receptors and is frequently prescribed in adults and children as an antiemetic or a prokinetic drug to control symptoms of upper gastrointestinal motor disorders. Metoclopramide is predominantly metabolized via N-dealkylation and it is primarily mediated by CYP2D6 which is highly polymorphic. Thus, the effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide were evaluated in this study. All volunteers were genotyped for CYP2D6 and divided into four different genotype groups (CYP2D6*wt/*wt [*wt = *1 or *2], CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10). Each subject received a single oral dose of metoclopramide 10 mg. Plasma concentrations of metoclopramide were measured by using HPLC-UV. Compared to CYP2D6*wt/*wt, AUCinf of CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10 significantly increased by 1.5-, 2.3-, and 2.5-fold, respectively. Cmax also increased significantly in comparison to CYP2D6*wt/*wt across all genotype groups, with 1.5-, 1.7-, and 1.7-fold increases seen in CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10 groups, respectively. The CL/F of metoclopramide decreased in CYP2D6 genotype groups with decreased function alleles, as decreases of 37%, 56% and 61% were observed in CYP2D6*wt/10, *10/10, and *5/*10 genotype groups in comparison to the CYP2D6*wt/*wt group. In conclusion, the genetic polymorphisms of CYP2D6 significantly affected metoclopramide pharmacokinetics.

Original languageEnglish
Pages (from-to)1207-1213
Number of pages7
JournalArchives of Pharmacal Research
Volume43
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • CYP2D6
  • Genetic polymorphism
  • Genotype
  • Metoclopramide
  • Pharmacokinetics

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