Abstract
The time-dependent (2-h, 24-h, and 96-h) effects of Escherichia coli lipopolysaccharide (ECLPS) on the intravenous (100mg kg-1) and oral (100mg kg-1) metformin pharmacokinetics were evaluated in rats. After the intravenous administration of metformin to 24-h and 96-h ECLPS rats, the total area under the plasma concentrationtime curve from time zero to time infinity (AUCs) and time-averaged non-renal clearances (CLNRs) of metformin were significantly greater and slower, respectively, than the controls. However, after the oral administration of metformin, the AUCs of metformin were comparable among four groups of rats. The greater (slower) intravenous AUCs (CLNRs) of metformin in 24-h and 96-h ECLPS rats were due to the slower hepatic intrinsic clearance (CLint) because of a decrease in the protein expression of hepatic cytochrome P450 (CYP) 2C11 and/or CYP3A subfamily than controls. The comparable oral AUCs among four groups of rats were mainly due to the comparable gastrointestinal metabolism (CL int).
Original language | English |
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Pages (from-to) | 946-954 |
Number of pages | 9 |
Journal | Xenobiotica |
Volume | 39 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2009 |
Keywords
- 2-h
- 24-h
- And 96-h Escherichia coli lipopolysaccharide (ECLPS) rats
- And CYP2D and CYP3A subfamilies
- Hepatic and intestinal CYP2C11
- Metformin
- Pharmacokinetics
- Rats