Effects of excessive fibrin deposit and polylactide adhesion barrier on wound healing in thyroidectomy murine wound model

Yun Sung Lim, Hee Bok Kim, Joo Hyun Park, Chang Gun Cho, Seok Won Park, Jae Suk Lee, Eo Jin Kim, Seong Keun Kwon

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: We hypothesize that excessive fibrin formation and inflammation induced by antiadhesive material, SurgiWrap (SW), would have an adverse effect on wound healing. It was evaluated by a thyroidectomy murine wound model. Methods: Excessive fibrin formation was induced by isthmectomy without hemostasis. Rats were allocated into isthmectomy with SurgiWrap (I+SW+), I+SW-, I-SW+, I-SW-, and isthmectomy after electrocautery for hemostasis (I+C+SW-). The SWs were placed on the superficial and visceral layers for gross and microscopic evaluation. Results: Microscopic examination showed collagen deposition occurred in the I-SW- sham group and at a higher level in I+C+SW-. The collagen deposition decreased in groups without SW with time but increased in groups with SW. Use of SW produced more inflammation and more collagen deposition. The I+SW + group developed the largest area of collagen deposition at 4 weeks and more collagen deposition than the I-SW + group. Conclusion: The SW induced more collagen deposition increasing with time. The collagen deposition produced by SW was worsened by excessive fibrin formation and inflammation.

Original languageEnglish
Pages (from-to)1207-1213
Number of pages7
JournalHead and Neck
Volume40
Issue number6
DOIs
StatePublished - Jun 2018

Keywords

  • fibrin
  • inflammation
  • thyroidectomy
  • tissue adhesions
  • wound healing

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