Effects of magnetic nanoparticle-incorporated human bone marrow-derived mesenchymal stem cells exposed to pulsed electromagnetic fields on injured rat spinal cord

Hyunjin Cho; Yun Kyong Choi; Dong Heon Lee; Hee Jung Park; Young Kwon Seo; Hyun Jung; Soo Chan Kim; Sung Min Kim; Jung Keug Park

doi:10.1002/bab.1109

Effects of magnetic nanoparticle-incorporated human bone marrow-derived mesenchymal stem cells exposed to pulsed electromagnetic fields on injured rat spinal cord

Hyunjin Cho, Yun Kyong Choi, Dong Heon Lee, Hee Jung Park, Young Kwon Seo, Hyun Jung, Soo Chan Kim, Sung Min Kim, Jung Keug Park

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Transplanting mesenchymal stem cells into injured lesions is currently under study as a therapeutic approach for spinal cord injury. In this study, the effects of a pulsed electromagnetic field (PEMF) on injured rat spinal cord were investigated in magnetic nanoparticle (MNP)-incorporated human bone marrow-derived mesenchymal stem cells (hBM-MSCs). A histological analysis revealed significant differences in MNP-incorporated cell distribution near the injured site under the PEMF in comparison with that in the control group. We confirmed that MNP-incorporated cells were widely distributed in the lesions under PEMF. The results suggest that MNP-incorporated hBM-MSCs were guided by the PEMF near the injured site, and that PEMF exposure for 8 H per day over 4 weeks promoted behavioral recovery in spinal cord injured rats. The results show that rats with MNP-incorporated hBM-MSCs under a PEMF were more effective on the Basso, Beattie, and Bresnahan behavioral test and suggest that the PEMF enhanced the action of transplanted cells for recovery of the injured lesion.

Original language	English
Pages (from-to)	596-602
Number of pages	7
Journal	Biotechnology and Applied Biochemistry
Volume	60
Issue number	6
DOIs	https://doi.org/10.1002/bab.1109
State	Published - Nov 2013

Keywords

human bone marrow-derived mesenchymal stem cells
magnetic nanoparticle
pulsed electromagnetic field
spinal cord injury

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10.1002/bab.1109

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title = "Effects of magnetic nanoparticle-incorporated human bone marrow-derived mesenchymal stem cells exposed to pulsed electromagnetic fields on injured rat spinal cord",

abstract = "Transplanting mesenchymal stem cells into injured lesions is currently under study as a therapeutic approach for spinal cord injury. In this study, the effects of a pulsed electromagnetic field (PEMF) on injured rat spinal cord were investigated in magnetic nanoparticle (MNP)-incorporated human bone marrow-derived mesenchymal stem cells (hBM-MSCs). A histological analysis revealed significant differences in MNP-incorporated cell distribution near the injured site under the PEMF in comparison with that in the control group. We confirmed that MNP-incorporated cells were widely distributed in the lesions under PEMF. The results suggest that MNP-incorporated hBM-MSCs were guided by the PEMF near the injured site, and that PEMF exposure for 8 H per day over 4 weeks promoted behavioral recovery in spinal cord injured rats. The results show that rats with MNP-incorporated hBM-MSCs under a PEMF were more effective on the Basso, Beattie, and Bresnahan behavioral test and suggest that the PEMF enhanced the action of transplanted cells for recovery of the injured lesion.",

keywords = "human bone marrow-derived mesenchymal stem cells, magnetic nanoparticle, pulsed electromagnetic field, spinal cord injury",

author = "Hyunjin Cho and Choi, {Yun Kyong} and Lee, {Dong Heon} and Park, {Hee Jung} and Seo, {Young Kwon} and Hyun Jung and Kim, {Soo Chan} and Kim, {Sung Min} and Park, {Jung Keug}",

year = "2013",

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doi = "10.1002/bab.1109",

language = "English",

volume = "60",

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AU - Cho, Hyunjin

AU - Choi, Yun Kyong

AU - Lee, Dong Heon

AU - Park, Hee Jung

AU - Seo, Young Kwon

AU - Jung, Hyun

AU - Kim, Soo Chan

AU - Kim, Sung Min

AU - Park, Jung Keug

PY - 2013/11

Y1 - 2013/11

N2 - Transplanting mesenchymal stem cells into injured lesions is currently under study as a therapeutic approach for spinal cord injury. In this study, the effects of a pulsed electromagnetic field (PEMF) on injured rat spinal cord were investigated in magnetic nanoparticle (MNP)-incorporated human bone marrow-derived mesenchymal stem cells (hBM-MSCs). A histological analysis revealed significant differences in MNP-incorporated cell distribution near the injured site under the PEMF in comparison with that in the control group. We confirmed that MNP-incorporated cells were widely distributed in the lesions under PEMF. The results suggest that MNP-incorporated hBM-MSCs were guided by the PEMF near the injured site, and that PEMF exposure for 8 H per day over 4 weeks promoted behavioral recovery in spinal cord injured rats. The results show that rats with MNP-incorporated hBM-MSCs under a PEMF were more effective on the Basso, Beattie, and Bresnahan behavioral test and suggest that the PEMF enhanced the action of transplanted cells for recovery of the injured lesion.

AB - Transplanting mesenchymal stem cells into injured lesions is currently under study as a therapeutic approach for spinal cord injury. In this study, the effects of a pulsed electromagnetic field (PEMF) on injured rat spinal cord were investigated in magnetic nanoparticle (MNP)-incorporated human bone marrow-derived mesenchymal stem cells (hBM-MSCs). A histological analysis revealed significant differences in MNP-incorporated cell distribution near the injured site under the PEMF in comparison with that in the control group. We confirmed that MNP-incorporated cells were widely distributed in the lesions under PEMF. The results suggest that MNP-incorporated hBM-MSCs were guided by the PEMF near the injured site, and that PEMF exposure for 8 H per day over 4 weeks promoted behavioral recovery in spinal cord injured rats. The results show that rats with MNP-incorporated hBM-MSCs under a PEMF were more effective on the Basso, Beattie, and Bresnahan behavioral test and suggest that the PEMF enhanced the action of transplanted cells for recovery of the injured lesion.

KW - human bone marrow-derived mesenchymal stem cells

KW - magnetic nanoparticle

KW - pulsed electromagnetic field

KW - spinal cord injury

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Effects of magnetic nanoparticle-incorporated human bone marrow-derived mesenchymal stem cells exposed to pulsed electromagnetic fields on injured rat spinal cord

Abstract

Keywords

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