Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

Pei Huang; Yuan Yuan Li; Jung E. Park; Ping Huang; Qin Xiao; Ying Wang; Sheng Chen; Sheng Di Chen; Jun Liu; Yi Wen Wu

doi:10.1017/cjn.2021.42

Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

Pei Huang, Yuan Yuan Li, Jung E. Park, Ping Huang, Qin Xiao, Ying Wang, Sheng Chen, Sheng Di Chen, Jun Liu, Yi Wen Wu

Department of Medicine

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Canadian Journal of Neurological Sciences
Volume	49
Issue number	1
DOIs	https://doi.org/10.1017/cjn.2021.42
State	Published - 9 Jan 2022

Keywords

Botulinum toxin A
Foot dystonia
Gait
Parkinson's disease

Access to Document

10.1017/cjn.2021.42

Cite this

@article{3fd6b27bca0c41d0bd52514f76b0bf3a,

title = "Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia",

abstract = "We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.",

keywords = "Botulinum toxin A, Foot dystonia, Gait, Parkinson's disease",

author = "Pei Huang and Li, {Yuan Yuan} and Park, {Jung E.} and Ping Huang and Qin Xiao and Ying Wang and Sheng Chen and Chen, {Sheng Di} and Jun Liu and Wu, {Yi Wen}",

note = "Publisher Copyright: {\textcopyright} ",

year = "2022",

month = jan,

day = "9",

doi = "10.1017/cjn.2021.42",

language = "English",

volume = "49",

pages = "123--128",

journal = "Canadian Journal of Neurological Sciences",

issn = "0317-1671",

publisher = "Cambridge University Press",

number = "1",

}

TY - JOUR

T1 - Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

AU - Huang, Pei

AU - Li, Yuan Yuan

AU - Park, Jung E.

AU - Huang, Ping

AU - Xiao, Qin

AU - Wang, Ying

AU - Chen, Sheng

AU - Chen, Sheng Di

AU - Liu, Jun

AU - Wu, Yi Wen

N1 - Publisher Copyright: ©

PY - 2022/1/9

Y1 - 2022/1/9

N2 - We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

AB - We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

KW - Botulinum toxin A

KW - Foot dystonia

KW - Gait

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=85122785084&partnerID=8YFLogxK

U2 - 10.1017/cjn.2021.42

DO - 10.1017/cjn.2021.42

M3 - Article

C2 - 33685541

AN - SCOPUS:85122785084

SN - 0317-1671

VL - 49

SP - 123

EP - 128

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

IS - 1

ER -

Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this