Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

Pei Huang; Yuan Yuan Li; Jung E. Park; Ping Huang; Qin Xiao; Ying Wang; Sheng Chen; Sheng Di Chen; Jun Liu; Yi Wen Wu

doi:10.1017/cjn.2021.42

Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

Pei Huang
, Yuan Yuan Li
, Jung E. Park
, Ping Huang
, Qin Xiao
, Ying Wang
, Sheng Chen
, Sheng Di Chen
, Jun Liu
, Yi Wen Wu

Department of Medicine

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Canadian Journal of Neurological Sciences
Volume	49
Issue number	1
DOIs	https://doi.org/10.1017/cjn.2021.42
State	Published - 9 Jan 2022

Keywords

Botulinum toxin A
Foot dystonia
Gait
Parkinson's disease

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title = "Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia",

abstract = "We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.",

keywords = "Botulinum toxin A, Foot dystonia, Gait, Parkinson's disease",

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AU - Huang, Pei

AU - Li, Yuan Yuan

AU - Park, Jung E.

AU - Huang, Ping

AU - Xiao, Qin

AU - Wang, Ying

AU - Chen, Sheng

AU - Chen, Sheng Di

AU - Liu, Jun

AU - Wu, Yi Wen

N1 - Publisher Copyright: ©

PY - 2022/1/9

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N2 - We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

AB - We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

KW - Botulinum toxin A

KW - Foot dystonia

KW - Gait

KW - Parkinson's disease

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JO - Canadian Journal of Neurological Sciences

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ER -

Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia

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Keywords

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