Efficacy and tolerability of HDMHG0401-10 in patients with androgenetic alopecia-a randomized double-blind placebo-controlled trial

Seung Ho Lee, Dong Hun Lee, Oh Sang Kwon, Hee Chul Eun

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background : Androgenetic alopecia (AGA) is an androgen-dependent hereditary disorder. Compared to the past, a rising number of patients with AGA have been seeking treatment. Oral finasteride and topical minoxidil are the only drugs approved, till now, by the Food and Drug Administration of USA for the treatment of this condition. Unfortunately, these treatment options are not satisfactory. Therefore, it has been necessary to develop new drugs for this psychologically frustrating disease. Methods : This is a 24-week, double-blinded, placebo-controlled, randomized clinical trial to determine whether a new topical treatment, HDMHG0401-10, is effective in showing clinical improvements in patients with AGA. A total of 41 men (23-49 years old) with AGA were treated either with the topical HDMHG0401-10 solution or a placebo, twice daily. Efficacy was evaluated by phototrichogram as well as patients' subjective and investigator's photographic assessments for change in hair density. Results : After 24 weeks of therapy, topical HDMHG0401-10 treatment resulted in significant improvement from the baseline in total hair count and showed to be significantly superior to the placebo in terms of hair loss count. There was no statistically significant difference in patients' and investigator's hair growth ratings between the HDMHG0401-10 treated and placebo groups. HDMHG0401-10 was generally well tolerated. Conclusion : We have confirmed the efficacy of HDMHG0401-10 in treating AGA in men, by an objective assessment with phototrichogram. No evidence of major side effects was seen.

Original languageEnglish
Pages (from-to)174-185
Number of pages12
JournalJournal of Korean Society for Clinical Pharmacology and Therapeutics
Volume13
Issue number2
DOIs
StatePublished - 2005

Keywords

  • Androgenetic alopecia
  • Hair growth
  • Phototrichogram

Fingerprint

Dive into the research topics of 'Efficacy and tolerability of HDMHG0401-10 in patients with androgenetic alopecia-a randomized double-blind placebo-controlled trial'. Together they form a unique fingerprint.

Cite this