Electrochemical DNA hybridization sensors based on conducting polymers

Md Mahbubur Rahman, Xiao Bo Li, Nasrin Siraj Lopa, Sang Jung Ahn, Jae Joon Lee

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations

Abstract

Conducting polymers (CPs) are a group of polymeric materials that have attracted considerable attention because of their unique electronic, chemical, and biochemical properties. This is reflected in their use in a wide range of potential applications, including light-emitting diodes, anti-static coating, electrochromic materials, solar cells, chemical sensors, biosensors, and drug-release systems. Electrochemical DNA sensors based on CPs can be used in numerous areas related to human health. This review summarizes the recent progress made in the development and use of CP-based electrochemical DNA hybridization sensors. We discuss the distinct properties of CPs with respect to their use in the immobilization of probe DNA on electrode surfaces, and we describe the immobilization techniques used for developing DNA hybridization sensors together with the various transduction methods employed. In the concluding part of this review, we present some of the challenges faced in the use of CP-based DNA hybridization sensors, as well as a future perspective.

Original languageEnglish
Pages (from-to)3801-3829
Number of pages29
JournalSensors
Volume15
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Conducting polymers
  • Electrochemical DNA sensors
  • Immobilization techniques
  • Transduction mechanism

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