Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome

Sang Woo Oh, Sangyeoup Lee, Cheolyoung Park, Dong Jun Kim

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

Background and aim: Elevated intraocular pressure (IOP), a well-known risk factor for glaucoma, has recently been shown to be associated with some metabolic complications and obesity. We investigated the link between IOP and metabolic disturbances, focusing especially on metabolic syndrome and insulin resistance. Methods: Eye examinations, including IOP measurement, were conducted on 943 subjects (533 men and 410 women). Body mass index (BMI), percent body fat, waist circumference, systolic and diastolic pressure, fasting insulin, glucose, lipids, and other metabolic parameters were measured. The homeostasis model assessment (HOMA) score and McAuley index were calculated to assess whole-body insulin resistance. Results: Both of these insulin resistance indices showed positive associations with IOP (p < 0.05), even after statistical adjustment for other risk factors. IOP was higher in participants with metabolic syndrome, as compared to those who did not have metabolic syndrome. The mean IOP tended to increase linearly with the presence of increasing numbers of components for metabolic syndrome. Conclusions: These results suggest that insulin resistance might contribute to an explanation that would account for many previous findings concerning the association between IOP and obesity, hypertension, and diabetes.

Original languageEnglish
Pages (from-to)434-440
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume21
Issue number5
DOIs
StatePublished - Sep 2005

Keywords

  • Insulin resistance
  • Intraocular pressure
  • Metabolic syndrome

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