Embryonic stem cells and induced pluripotent stem cells for skeletal regeneration

Siyeon Park, Gun Il Im

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Tissue engineering for skeletal tissues including bone and cartilage have been focused on the use of adult stem cells. Although there are several pioneering researches on skeletal tissue regeneration from embryonic stem cells (ESCs), ethical issues and the possibility of immune rejection clouded further attention to the application of ESCs for nonlethal orthopedic conditions. However, the recent discovery of induced pluripotent stem cells (iPSCs) led to reconsider the use of these pluripotential cells for skeletal regeneration. The purpose of this review was to summarize the current knowledge of osteogenic and chondrogenic induction from ESCs and iPSCs and to provide a perspective on the application of iPSCs for skeletal regeneration.

Original languageEnglish
Pages (from-to)381-391
Number of pages11
JournalTissue Engineering - Part B: Reviews
Volume20
Issue number5
DOIs
StatePublished - 1 Oct 2014

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