Emergence of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Clinical Isolates among Daptomycin-Naive Patients in Korea

Eun Young Nam, Soo Jin Yang, Eu Suk Kim, Jeong Eun Cho, Kyung Hwa Park, Sook In Jung, Nara Yoon, Dong Min Kim, Chang Seop Lee, Hee Chang Jang, Yoonseon Park, Kkot Sil Lee, Yee Gyung Kwak, Jae Hoon Lee, Seong Yeon Park, Joo Hee Hwang, Moonsuk Kim, Kyoung Ho Song, Hong Bin Kim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This study was conducted to assess emergence of daptomycin-nonsusceptible (DAP-NS) phenotype in DAP-naive patients with invasive Staphylococcus aureus (ISA) infections in Korea. A total of 208 S. aureus clinical isolates were selected from a previous prospective study on ISA infections and evaluated for DAP-NS. Although DAP has never been introduced in Korea, five DAP-NS S. aureus strains (2.4%) were identified among 208 S. aureus strains collected from ISA infections. The DAP-NS phenotype was observed only in methicillin-resistant S. aureus (MRSA) strains, but not in methicillin-susceptible S. aureus strains. One DAP-NS MRSA strain belonged to sequence type 72 (ST72) and four were ST5 MRSA strains, three of which were heteroresistant vancomycin (VAN)-intermediate S. aureus. All these five DAP-NS MRSA strains were from healthcare-associated infections without prior exposure to VAN within 30 days. While the ST72 MRSA strain exhibited DAP-NS phenotype via charge repulsion mechanism, four ST5 DAP-NS S. aureus strains had charge-independent DAP-NS mechanism. None of the five DAP-NS strains displayed significant increase in cell wall thickness, indicating that altered cell wall thickness was not associated with the observed DAP-NS phenotype.

Original languageEnglish
Pages (from-to)534-541
Number of pages8
JournalMicrobial Drug Resistance
Volume24
Issue number5
DOIs
StatePublished - Jun 2018

Keywords

  • daptomycin resistance
  • Staphylococcus aureus
  • vancomycin

Fingerprint

Dive into the research topics of 'Emergence of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Clinical Isolates among Daptomycin-Naive Patients in Korea'. Together they form a unique fingerprint.

Cite this