Engineering a 3D neural circuit, blood-brain barrier, and myelination in microfluidic 96 well plate

Seung Ryeol Lee, Sujin Hyung, Seokyoung Bang, Noo Li Jeon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Microfluidic devices based on polydimethylsiloxane (PDMS) facilitate research in the fields of neuroscience. However, wider applications of these platforms to high-content or high-throughput drug screening are still challenging due to inherent material properties and lack of standardized manufactural devices. Here, we present an injection molded three-dimensional (3D) neuron culture platform with 96-well plate format (Neuro-IMPACT) that can recapitulate elements of the nervous system such as neural circuit, blood-brain barrier, and myelination. A standardized in vitro platform with a new patterning method allow high-throughput experiments. The platform enables not only long-term 3D neuron culture, but also co-culture to assist neuroscience research.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages450-451
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • 3D culture platform
  • High-throughput screening
  • Microfluidics
  • Nervous system
  • Organ-on-a-chip

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