Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population

Yun Jeong Lim, Jong Woo Kim, Ji Young Song, Mee Suk Hong, Sheng Yu Jin, Seo Hyun Yoon, Hae Jeong Park, Bong Keun Choe, Jung Joo Lee, Sung Vin Yim, Seok Il Hong, Hyung Hwan Baik, Eunyoung Ha, Yeon Hee Park

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32 Scopus citations

Abstract

Low incidence of cancer in schizophrenia is one of the interesting puzzles in psychiatric field over decades. Analysis of genetic difference between schizophrenia and lung cancer might provide us with possible clues to understand molecular mechanisms of pathophysiology of schizophrenia. Epidermal growth factor (EGF), one of the potent growth promoting factors, has been studied for its roles in cancer development. EGF is also known to be involved in cognitive function. In order to analyze the genetic difference between schizophrenia and lung cancer, polymorphism of EGF gene was studied from 174 schizophrenia patients, 122 lung cancer patients and 132 controls in Korean population. Genotype frequency analysis of EGF gene (AluI restriction site, 5′-UTR, rs4444903) in the EGF gene was studied. The genotype and allele frequencies of the AluI polymorphism showed significant differences between schizophrenia and lung cancer patients [p < 0.0001; p < 0.0001, odds ratio (95% CI), 0.3690 (0.2600-0.5236)]. When compared with controls, schizophrenia patients showed no significant differences from controls in genotype and allele frequencies [p = 0.5151; p = 0.3516, odds ratio (95% CI), 0.8589 (0.6235-1.1830)]. However, lung cancer patients showed significant differences from controls in genotype and allele frequencies [p < 0.0001; p < 0.0001, odds ratio (95% CI), 2.3275 (1.6082-3.3687)]. These results indicate that schizophrenia is not associated with AluI polymorphism of EGF gene and EGF gene polymorphism is different between schizophrenia and lung cancer patients.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalNeuroscience Letters
Volume374
Issue number3
DOIs
StatePublished - 21 Feb 2005

Keywords

  • Epidermal growth factor (EGF)
  • Lung cancer
  • Polymorphism
  • Schizophrenia

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