Epithelial-mesenchymal transition: Initiation by cues from chronic inflammatory tumor microenvironment and termination by anti-inflammatory compounds and specialized pro-resolving lipids

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Abstract

Epithelial mesenchymal transition (EMT) is a biological process that plays a critical role in cancer progression. Blocking the process of EMT can be an essential strategy in the development of anticancer drugs. In this paper, we briefly introduce recent research trends and issues of EMT, focusing on the relationship of EMT with the entire cycle of inflammation (from initiation to resolution of inflammation). Recent findings on the relationship between EMT and immune evasion are discussed. We will also explore the importance of controlling inflammation by anti-inflammatory compounds and specialized pro-resolving lipids to inhibit EMT process in cancer.

Original languageEnglish
Pages (from-to)261-273
Number of pages13
JournalBiochemical Pharmacology
Volume158
DOIs
StatePublished - Dec 2018

Keywords

  • Anti-inflammatory compounds
  • Epithelial mesenchymal transition
  • Immune evasion
  • Inflammation
  • Pro-resolving specialized lipids

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