TY - JOUR
T1 - Essential oils and mono/Bi/tri-metallic nanocomposites as alternative sources of antimicrobial agents to combat multidrug-resistant pathogenic microorganisms
T2 - An overview
AU - Basavegowda, Nagaraj
AU - Patra, Jayanta Kumar
AU - Baek, Kwang Hyun
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
PY - 2020/2/27
Y1 - 2020/2/27
N2 - Over the past few decades, many pathogenic bacteria have become resistant to existing antibiotics, which has become a threat to infectious disease control worldwide. Hence, there has been an extensive search for new, efficient, and alternative sources of antimicrobial agents to combat multidrug-resistant pathogenic microorganisms. Numerous studies have reported the potential of both essential oils and metal/metal oxide nanocomposites with broad spectra of bioactivities including antioxidant, anticancer, and antimicrobial attributes. However, only monometallic nanoparticles combined with essential oils have been reported on so far with limited data. Bi- and tri-metallic nanoparticles have attracted immense attention because of their diverse sizes, shapes, high surface-to-volume ratios, activities, physical and chemical stability, and greater degree of selectivity. Combination therapy is currently blooming and represents a potential area that requires greater attention and is worthy of future investigations. This review summarizes the synergistic effects of essential oils with other antimicrobial combinations such as mono-, bi-, and tri-metallic nanocomposites. Thus, the various aspects of this comprehensive review may prove useful in the development of new and alternative therapeutics against antibiotic resistant pathogens in the future.
AB - Over the past few decades, many pathogenic bacteria have become resistant to existing antibiotics, which has become a threat to infectious disease control worldwide. Hence, there has been an extensive search for new, efficient, and alternative sources of antimicrobial agents to combat multidrug-resistant pathogenic microorganisms. Numerous studies have reported the potential of both essential oils and metal/metal oxide nanocomposites with broad spectra of bioactivities including antioxidant, anticancer, and antimicrobial attributes. However, only monometallic nanoparticles combined with essential oils have been reported on so far with limited data. Bi- and tri-metallic nanoparticles have attracted immense attention because of their diverse sizes, shapes, high surface-to-volume ratios, activities, physical and chemical stability, and greater degree of selectivity. Combination therapy is currently blooming and represents a potential area that requires greater attention and is worthy of future investigations. This review summarizes the synergistic effects of essential oils with other antimicrobial combinations such as mono-, bi-, and tri-metallic nanocomposites. Thus, the various aspects of this comprehensive review may prove useful in the development of new and alternative therapeutics against antibiotic resistant pathogens in the future.
KW - Antimicrobial activities
KW - Bi-metallic nanoparticles
KW - Essential oil
KW - Multidrug-resistant pathogens
KW - Synergistic effect
KW - Tri-metallic nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85080943428&partnerID=8YFLogxK
U2 - 10.3390/molecules25051058
DO - 10.3390/molecules25051058
M3 - Review article
C2 - 32120930
AN - SCOPUS:85080943428
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 5
M1 - 1058
ER -