TY - JOUR
T1 - Evaluation of medicinal values of Gymnopetalum chinense (Lour.) Merr., a lesser known cucurbit from Eastern Ghats of India
AU - Kumar, Sanjeet
AU - Das, Gitishree
AU - Shin, Han Seung
AU - Kumar, Pradeep
AU - Patra, Jayanta Kumar
PY - 2017
Y1 - 2017
N2 - The in vitro antimicrobial activity of Gymnopetulum chinense (Cucurbitaceae), a lesser known climber of Eastern Ghats and recently recorded species from Odisha, India was studied against five selected human pathogenic bacteria (Streptococcus mutans, S. pyogenes, Vibrio cholerae, Shigella flexneri and Salmonella typhi), by agar well diffusion (AWD), disc diffusion (DD) and broth dilution methods. Different solvent extracts were prepared from the leaves of G. chinense using various solvents viz. n-hexane, chloroform, methanol, acetone and aqueous. The nomenclature, detailed description and photographs of the plant are provided to facilitate its easy identification. The leaf extract showed presence of phenolic compounds, tannin, saponin, flavonoids and glycosides. It was examined that methanol extract showed highest zone of inhibition (16.66 mm) against S. pyogenes using DD assay. Similar results were examined as lowest MIC values were found with methanol leaf extract against S. pyogenes and S. mutans (200 μg/ml). Present study showed first report of this plant as natural antibacterial agents and highlights the importance of G. chinense in curing the bacterial infections.
AB - The in vitro antimicrobial activity of Gymnopetulum chinense (Cucurbitaceae), a lesser known climber of Eastern Ghats and recently recorded species from Odisha, India was studied against five selected human pathogenic bacteria (Streptococcus mutans, S. pyogenes, Vibrio cholerae, Shigella flexneri and Salmonella typhi), by agar well diffusion (AWD), disc diffusion (DD) and broth dilution methods. Different solvent extracts were prepared from the leaves of G. chinense using various solvents viz. n-hexane, chloroform, methanol, acetone and aqueous. The nomenclature, detailed description and photographs of the plant are provided to facilitate its easy identification. The leaf extract showed presence of phenolic compounds, tannin, saponin, flavonoids and glycosides. It was examined that methanol extract showed highest zone of inhibition (16.66 mm) against S. pyogenes using DD assay. Similar results were examined as lowest MIC values were found with methanol leaf extract against S. pyogenes and S. mutans (200 μg/ml). Present study showed first report of this plant as natural antibacterial agents and highlights the importance of G. chinense in curing the bacterial infections.
KW - Antibacterial activity
KW - Antimicrobial resistance
KW - Cucurbits
KW - Gymnopetulum chinense
KW - Streptococcus pyogenes
UR - http://www.scopus.com/inward/record.url?scp=85041576481&partnerID=8YFLogxK
U2 - 10.1590/1678-4324-2017160580
DO - 10.1590/1678-4324-2017160580
M3 - Article
AN - SCOPUS:85041576481
SN - 1516-8913
VL - 60
JO - Brazilian Archives of Biology and Technology
JF - Brazilian Archives of Biology and Technology
M1 - e17160580
ER -