Evaluation of polycyclic aromatic hydrocarbons content of herbal medicine products in Korea by HPLC-FLD

Yong Yeon Kim, Han Seung Shin

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to quantify four polycyclic aromatic hydrocarbons (PAH4) in herbal medicine products in Korea. The PAH4 (benzo[a]anthracene, benzo[b]fluoranthene, chrysene, and benzo[a]pyrene) were analyzed in 70 popularly used herbal medicine products without containing essential oil and containing essential oil matrices, using 3-methylcholanthrene as the internal standard. Ultrasonication and liquid–liquid extraction were followed by HPLC-FLD analysis. Satisfactory linearity (R2 = 0.99), limit of detection (0.05–0.18 μg/kg), limit of quantification (0.14–0.54 μg/kg), recovery (85.72–112.18%), and precision (0.22–2.90%) of PAH4 were acquired. PAH contamination was detected in all herbal medicine products without containing essential oil and containing essential oil matrices types. In 44 samples of herbal medicine products, all PAH4 were detected, and in two samples of the other herbal medicine products, only benzo[b]fluoranthene was detected. The average concentration of PAH4 was 3.88 μg/kg. The validated analytical method was used for preventing human health risks related to the consumption of herbal medicines.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalFood Science and Biotechnology
Volume32
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • Average concentration
  • Fluorescence detector
  • Herbal medicine product
  • High-performance liquid chromatography
  • Polycyclic aromatic hydrocarbon

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