Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides

Sang Uk Kang, Jun Choi Won, Shinya Oishi, Kyeong Lee, Rajeshri G. Karki, Karen M. Worthy, Lakshman K. Bindu, Marc C. Nicklaus, Robert J. Fisher, Terrence R. Burke

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Abstract

A 4-aminopiperidine-4-carboxylic acid residue was placed in the pTyr+1 position of a Grb2 SH2 domain-binding peptide to form a general platform, which was then acylated with a variety of groups to yield a library of compounds designed to explore potential binding interactions, with protein features lying below the βD strand. The highest affinities were obtained using phenylethyl carbamate and phenylbutyrylamide functionalities.

Original languageEnglish
Pages (from-to)1978-1982
Number of pages5
JournalJournal of Medicinal Chemistry
Volume50
Issue number8
DOIs
StatePublished - 19 Apr 2007

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