Abstract
A 4-aminopiperidine-4-carboxylic acid residue was placed in the pTyr+1 position of a Grb2 SH2 domain-binding peptide to form a general platform, which was then acylated with a variety of groups to yield a library of compounds designed to explore potential binding interactions, with protein features lying below the βD strand. The highest affinities were obtained using phenylethyl carbamate and phenylbutyrylamide functionalities.
Original language | English |
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Pages (from-to) | 1978-1982 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 50 |
Issue number | 8 |
DOIs | |
State | Published - 19 Apr 2007 |