Expression of caveolin-3 immunoreactivities in the developing sciatic nerve of the rat

Ho J. Lee, Choong H. Park, Seong J. Lee, Jin W. Park, Jong H. Choi, Gi H. Ryu, Bum S. Kwon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Caveolae are formed by the caveolin (CAV) family of proteins, CAV-1, -2, and -3. CAV-1 and -2 are co-expressed in many cell types, whereas CAV-3 is muscle-specific and mutation of the CAV-3 gene causes muscular dystrophy. CAV-3 has also been detected in brain astroglial cells and in peripheral nerves along with CAV-1. Therefore, we sought to determine whether CAV-3 protein is expressed in developing peripheral nerves by using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). We found that CAV-3 immunoreactivities (IRs) were localized in the myelin sheath during peripheral nerve development. CAV-3 IRs were intense during the early postnatal stage, but decreased as the peripheral nerves matured at postnatal weeks 3-5. CAV-3 mRNA expression was also markedly decreased during postnatal development. Because the expression pattern of CAV-3 IRs was opposite that of CAV-1 IRs, CAV-1 and -3 might be involved in different phases of peripheral nerve myelination and play complementary roles in myelin maturation and peripheral nerve development.

Original languageEnglish
Pages (from-to)1021-1026
Number of pages6
JournalMuscle and Nerve
Volume38
Issue number2
DOIs
StatePublished - Aug 2008

Keywords

  • Caveolin-3
  • Immunohistochemistry
  • Myelination
  • Peripheral nerve
  • Schwann cell

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