Extracellular matrix and natural polymers for tissue engineering and regenerative medicine

Young Kwon Seo, Hee Hoon Youn, Jung Keug Park

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Natural polymers and extracellular matrix materials have various advantages as cell culture systems and are widely used as scaffolds for tissue engineering and in regenerative medicine. These materials show excellent biocompatibility and safety due to their biological characteristics, which include biodegradability and weak antigenicity. Therefore, these materials have been used for tissue engineering including synthesis of artificial skin, bone, cartilage, vessels, and cornea, and as substrates in cell culture and delivery. Biological matrices such as acellular dermis, amniotic membrane, and small intestine submucosa have been employed in numerous wound-healing applications. The safety and efficacy of biological matrices have been demonstrated in preclinical animal studies and in clinical work when used for bone, tendon, ligament, vessel, urinary organ, and skin regeneration. This article discusses commercially available natural polymers and extracellular matrices and their use in research and clinical applications.

Original languageEnglish
Pages (from-to)1088-1106
Number of pages19
JournalTissue Engineering and Regenerative Medicine
Volume6
Issue number12
StatePublished - Sep 2009

Keywords

  • Biodegradability
  • Extracellulan Matnix
  • Polysaccharidic poltmers

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