Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Young Bock Shim; Hong Hee Jung; Ju Woong Jang; Hee Seok Yang; Hojae Bae; Jong Chul Park; Bogyu Choi; Soo Hong Lee

doi:10.1016/j.jiec.2016.03.014

Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Young Bock Shim, Hong Hee Jung, Ju Woong Jang, Hee Seok Yang, Hojae Bae, Jong Chul Park, Bogyu Choi, Soo Hong Lee

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Journal of Industrial and Engineering Chemistry
Volume	37
DOIs	https://doi.org/10.1016/j.jiec.2016.03.014
State	Published - 25 May 2016

Keywords

BMP2
Dexamethasone
Hollow porous microspheres
PLGA
Sucrose

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title = "Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2",

abstract = "Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.",

keywords = "BMP2, Dexamethasone, Hollow porous microspheres, PLGA, Sucrose",

author = "Shim, {Young Bock} and Jung, {Hong Hee} and Jang, {Ju Woong} and Yang, {Hee Seok} and Hojae Bae and Park, {Jong Chul} and Bogyu Choi and Lee, {Soo Hong}",

note = "Publisher Copyright: {\textcopyright} 2016 The Korean Society of Industrial and Engineering Chemistry.",

year = "2016",

month = may,

day = "25",

doi = "10.1016/j.jiec.2016.03.014",

language = "English",

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journal = "Journal of Industrial and Engineering Chemistry",

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T1 - Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

AU - Shim, Young Bock

AU - Jung, Hong Hee

AU - Jang, Ju Woong

AU - Yang, Hee Seok

AU - Bae, Hojae

AU - Park, Jong Chul

AU - Choi, Bogyu

AU - Lee, Soo Hong

PY - 2016/5/25

Y1 - 2016/5/25

N2 - Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

AB - Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

KW - BMP2

KW - Dexamethasone

KW - Hollow porous microspheres

KW - PLGA

KW - Sucrose

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U2 - 10.1016/j.jiec.2016.03.014

DO - 10.1016/j.jiec.2016.03.014

M3 - Article

AN - SCOPUS:84977939726

SN - 1226-086X

VL - 37

SP - 101

EP - 106

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Abstract

Keywords

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