Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Young Bock Shim; Hong Hee Jung; Ju Woong Jang; Hee Seok Yang; Hojae Bae; Jong Chul Park; Bogyu Choi; Soo Hong Lee

doi:10.1016/j.jiec.2016.03.014

Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Young Bock Shim
, Hong Hee Jung
, Ju Woong Jang
, Hee Seok Yang
, Hojae Bae
, Jong Chul Park
, Bogyu Choi
, Soo Hong Lee

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Journal of Industrial and Engineering Chemistry
Volume	37
DOIs	https://doi.org/10.1016/j.jiec.2016.03.014
State	Published - 25 May 2016

Keywords

BMP2
Dexamethasone
Hollow porous microspheres
PLGA
Sucrose

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10.1016/j.jiec.2016.03.014

Cite this

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title = "Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2",

abstract = "Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.",

keywords = "BMP2, Dexamethasone, Hollow porous microspheres, PLGA, Sucrose",

author = "Shim, \{Young Bock\} and Jung, \{Hong Hee\} and Jang, \{Ju Woong\} and Yang, \{Hee Seok\} and Hojae Bae and Park, \{Jong Chul\} and Bogyu Choi and Lee, \{Soo Hong\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Korean Society of Industrial and Engineering Chemistry.",

year = "2016",

month = may,

day = "25",

doi = "10.1016/j.jiec.2016.03.014",

language = "English",

volume = "37",

pages = "101--106",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

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TY - JOUR

T1 - Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

AU - Shim, Young Bock

AU - Jung, Hong Hee

AU - Jang, Ju Woong

AU - Yang, Hee Seok

AU - Bae, Hojae

AU - Park, Jong Chul

AU - Choi, Bogyu

AU - Lee, Soo Hong

PY - 2016/5/25

Y1 - 2016/5/25

N2 - Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

AB - Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.

KW - BMP2

KW - Dexamethasone

KW - Hollow porous microspheres

KW - PLGA

KW - Sucrose

UR - https://www.scopus.com/pages/publications/84977939726

U2 - 10.1016/j.jiec.2016.03.014

DO - 10.1016/j.jiec.2016.03.014

M3 - Article

AN - SCOPUS:84977939726

SN - 1226-086X

VL - 37

SP - 101

EP - 106

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Abstract

Keywords

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