Abstract
Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au-Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au-Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au-Ag nanoshell as a combinational chemo-thermotherapy to treat cancer cells.
Original language | English |
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Pages (from-to) | 467-475 |
Number of pages | 9 |
Journal | ACS Nano |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 28 Jan 2014 |
Keywords
- cancer
- dextran
- doxorubicin
- hollow nanoparticle
- photothermal therapy