Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy

Hongje Jang, Young Kwan Kim, Hyun Huh, Dal Hee Min

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au-Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au-Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au-Ag nanoshell as a combinational chemo-thermotherapy to treat cancer cells.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalACS Nano
Volume8
Issue number1
DOIs
StatePublished - 28 Jan 2014

Keywords

  • cancer
  • dextran
  • doxorubicin
  • hollow nanoparticle
  • photothermal therapy

Fingerprint

Dive into the research topics of 'Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy'. Together they form a unique fingerprint.

Cite this