Factors potentiating the risk of mirtazapine-associated restless legs syndrome

Sung Wan Kim, Il Seon Shin, Jae Min Kim, Kee Hyung Park, Tak Youn, Jin Sang Yoon

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Objective: Mirtazapine is known to often provoke restless legs syndrome (RLS). In this retrospective chart review study, we evaluated the socio-demographic and clinical factors related to mirtazapine-associated RLS. Methods: Computerized medical records of 181 patients treated with mirtazapine from May 2004 to October 2007 were reviewed. RLS was identified using the diagnostic criteria of the International RLS Study Group. Socio-demographic and clinical characteristics were gathered, including comorbid physical illness and concomitant medications. Results: Mirtazapine-associated RLS was observed in 14 patients (8%), and most cases had developed within a few days after starting mirtazapine. Concomitant medication with tramadol, non-opioid analgesics, antihistamine, and dopamine-blocking agents was more frequently prescribed in subjects developing mirtazapine-associated RLS. In logistic regression analysis, concomitant medication with tramadol (odds ratio: 8.61, 95% confidence interval: 1.71-43.49) and dopamine-blocking agents (odds ratio: 4.67, 95% confidence interval: 1.31-16.70) enhanced the risk of mirtazapine-associated RLS. Conclusion: The combined use of mirtazapine with tramadol or dopamine-blocking agents could potentiate the risk of RLS. Clinician should watch carefully for the development of RLS when mirtazapine is administered to patients who are taking tramadol or dopamine-blocking agents.

Original languageEnglish
Pages (from-to)615-620
Number of pages6
JournalHuman Psychopharmacology
Volume23
Issue number7
DOIs
StatePublished - 2008

Keywords

  • Antiemetic
  • Antihistamine
  • Dopamine
  • Mirtazapine
  • Restless legs syndrome
  • Tramadol

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