Abstract
Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression.
| Original language | English |
|---|---|
| Pages (from-to) | 203-210 |
| Number of pages | 8 |
| Journal | Journal of Controlled Release |
| Volume | 109 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 5 Dec 2005 |
Keywords
- Compressibility
- Compression
- Fast-melting tablets
- Highly plastic granules
- Plastic deformation
- Wet granulation