Abstract
Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.
Original language | English |
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Pages (from-to) | 5644-5647 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 24 |
Issue number | 24 |
DOIs | |
State | Published - 15 Dec 2014 |
Keywords
- Anti-allergy
- Arylbenzofruran
- Flavonoid
- Interleukin-6
- Sophora tonkinensis