Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Hunseung Yoo, Hee Sung Chae, Young Mi Kim, Minseok Kang, Keun Ho Ryu, Hee Chul Ahn, Kee Dong Yoon, Young Won Chin, Jinwoong Kim

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.

Original languageEnglish
Pages (from-to)5644-5647
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number24
DOIs
StatePublished - 15 Dec 2014

Keywords

  • Anti-allergy
  • Arylbenzofruran
  • Flavonoid
  • Interleukin-6
  • Sophora tonkinensis

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