Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Hunseung Yoo; Hee Sung Chae; Young Mi Kim; Minseok Kang; Keun Ho Ryu; Hee Chul Ahn; Kee Dong Yoon; Young Won Chin; Jinwoong Kim

doi:10.1016/j.bmcl.2014.10.077

Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Hunseung Yoo
, Hee Sung Chae
, Young Mi Kim
, Minseok Kang
, Keun Ho Ryu
, Hee Chul Ahn
, Kee Dong Yoon
, Young Won Chin
, Jinwoong Kim

Department of Pharmacy

Seoul National University
SK Corporation
Dongguk University
The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC₅₀ values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.

Original language	English
Pages (from-to)	5644-5647
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2014.10.077
State	Published - 15 Dec 2014

Keywords

Anti-allergy
Arylbenzofruran
Flavonoid
Interleukin-6
Sophora tonkinensis

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10.1016/j.bmcl.2014.10.077

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title = "Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity",

abstract = "Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.",

keywords = "Anti-allergy, Arylbenzofruran, Flavonoid, Interleukin-6, Sophora tonkinensis",

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doi = "10.1016/j.bmcl.2014.10.077",

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T1 - Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

AU - Yoo, Hunseung

AU - Chae, Hee Sung

AU - Kim, Young Mi

AU - Kang, Minseok

AU - Ryu, Keun Ho

AU - Ahn, Hee Chul

AU - Yoon, Kee Dong

AU - Chin, Young Won

AU - Kim, Jinwoong

PY - 2014/12/15

Y1 - 2014/12/15

N2 - Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.

AB - Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.

KW - Anti-allergy

KW - Arylbenzofruran

KW - Flavonoid

KW - Interleukin-6

KW - Sophora tonkinensis

UR - https://www.scopus.com/pages/publications/84911928389

U2 - 10.1016/j.bmcl.2014.10.077

DO - 10.1016/j.bmcl.2014.10.077

M3 - Article

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AN - SCOPUS:84911928389

SN - 0960-894X

VL - 24

SP - 5644

EP - 5647

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Abstract

Keywords

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