Flavonoids from Thyrsanthera suborbicularis and their NO inhibitory activity

Hyuk Hwan Song, Piseth Khiev, Hee Sung Chai, Hyeong Kyu Lee, Sei Ryang Oh, Young Hee Choi, Young Won Chin

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5 Scopus citations

Abstract

Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-β-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[α-L-rhamnopyranosyl-(13) -α-L-rhamnopyranosyl-(16)-β-D-galactopyranoside (6), kaempferol-3-O-α-L-rhamnopyranosyl(12)-O-[α-L-rhamnopyranosyl (16)]-β-D-glucopyranoside (7), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]- β-D-glucopyranoside (8), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]- β-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1-10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with IC50 values, 3.56 and 15.73 μM, respectively.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalNatural Product Sciences
Volume18
Issue number4
StatePublished - Dec 2012

Keywords

  • Flavonoids
  • Nitric oxide inhibition
  • Thyrsanthera suborbicularis

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