TY - JOUR
T1 - Flavonoids from Thyrsanthera suborbicularis and their NO inhibitory activity
AU - Song, Hyuk Hwan
AU - Khiev, Piseth
AU - Chai, Hee Sung
AU - Lee, Hyeong Kyu
AU - Oh, Sei Ryang
AU - Choi, Young Hee
AU - Chin, Young Won
PY - 2012/12
Y1 - 2012/12
N2 - Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-β-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[α-L-rhamnopyranosyl-(13) -α-L-rhamnopyranosyl-(16)-β-D-galactopyranoside (6), kaempferol-3-O-α-L-rhamnopyranosyl(12)-O-[α-L-rhamnopyranosyl (16)]-β-D-glucopyranoside (7), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]- β-D-glucopyranoside (8), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]- β-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1-10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with IC50 values, 3.56 and 15.73 μM, respectively.
AB - Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-β-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[α-L-rhamnopyranosyl-(13) -α-L-rhamnopyranosyl-(16)-β-D-galactopyranoside (6), kaempferol-3-O-α-L-rhamnopyranosyl(12)-O-[α-L-rhamnopyranosyl (16)]-β-D-glucopyranoside (7), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]- β-D-glucopyranoside (8), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]- β-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1-10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with IC50 values, 3.56 and 15.73 μM, respectively.
KW - Flavonoids
KW - Nitric oxide inhibition
KW - Thyrsanthera suborbicularis
UR - http://www.scopus.com/inward/record.url?scp=84874637452&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84874637452
SN - 1226-3907
VL - 18
SP - 273
EP - 278
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 4
ER -