Flavonostilbenes Isolated from the Stems of Rhamnoneuron balansae as Potential SIRT1 Activators

Hyo Moon Cho, Mi Zhang, Eun Jin Park, Ba Wool Lee, Yeon Joo Park, Hyun Woo Kim, Ha Thanh Tung Pham, Young Won Chin, Won Keun Oh

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The cumulative effects of cell damage result in aging, which gradually decreases human function in various aspects and leads to multiple age-related chronic diseases. To overcome the adverse effects of aging, silent mating type information regulation 2 homologue (SIRT1) activators are promising bioactive compounds that mimic calorie restriction to improve quality of life and prevent aging. In this study, 11 new flavonostilbenes (1–11) and three known compounds (12–14) were purified from stems of Rhamnoneuron balansae. The structures of the new compounds were determined using extensive data from spectroscopic methods, including NMR and HRESIMS. Their absolute configurations were deduced by ECD calculations with coupling constant analysis. All of the isolated new compounds (1–11) were evaluated for their effects on SIRT1 deacetylase activity, the NAD+/NADH ratio, and the AMP-activated protein kinase activation level in cell-based assays. The results showed that rhamnoneuronal D (1) exhibits promising biological activity in several in vitro models related to SIRT1 and suggest it is a potential natural-product-based antiaging agent.

Original languageEnglish
Pages (from-to)70-82
Number of pages13
JournalJournal of Natural Products
Volume85
Issue number1
DOIs
StatePublished - 28 Jan 2022

Fingerprint

Dive into the research topics of 'Flavonostilbenes Isolated from the Stems of Rhamnoneuron balansae as Potential SIRT1 Activators'. Together they form a unique fingerprint.

Cite this